I have always been fascinated with the User Experience, regardless of the medium. In retail stores or on the web. I have loved the store designs at Apple for instance on how they encourage you to touch and play and ask questions. Creating a good experience on the web is very important and there are many ways to do this. But you really need to learn to leverage the tools well and that can be a full time job in itself. I usually work from paper to get my ideas out, and then transfer them to a wire frame product (currently I am using iMockup) and then hand them off to a real designer to bring them to life.
While searching around for a clean straightforward social media monitoring tool I came across Swix. I loved the design and ease of the site so I dug into their blog and came across this great post from Craig Fitzpatrick — Vice President of Products. He uses Keynote to do all his work and then transfers it to iWeb.